Resveratrol & Curcumin Liposomal Sublingual Gel (60 Servings)

 84,95

  • 125 mg Resveratrol per serving
  • 75 mg Curcumin per serving
  • 1 serving = 2 pumps
  • 60 servings per bottle
  • Third party tested for purity (over 99%) and safety – see certificates attached
  • cGMP Certified – This product was made in an FDA approved facility
  • No artificial colours, flavours or preservatives. Non-GMO
  • Suitable for vegans

Liposomal Sublingual Gel™ (LSG) Curcumin & Resveratrol is designed for sublingual (under the tongue) use for superior bioavailability. Our proprietary liposomal manufacturing process uses no heat, no pressure and only high-performance, pharmaceutical-grade ingredients.

 

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Description

Resveratrol and Curcumin offer a powerhouse of antioxidant & anti-inflammatory benefits in this bioavailable liposomal gel. Resveratrol has shown great promise in clinical studies and is part of a group of compounds called polyphenols, which act as antioxidants to protect the body against age-related conditions. Curcumin is the active compound in turmeric and has an array of scientifically-proven health benefits.

Benefits May Include

  • Support for cellular energy and mitochondrial function
  • Activation of sirtuins, which are vital to regulating metabolic health, circadian rhythm, detoxification, and cellular aging
  • Cardiovascular & Immune system support
  • Support for joint health & inflammatory pain-related conditions

Bioavailability

Both resveratrol and curcumin are known to have poor bioavailability. In clinical studies, when resveratrol is taken orally, less than 1% of it makes it into the bloodstream, as it is rapidly and extensively metabolized in the intestines and liver. (Source)

Curcumin is known as a potent compound, but its full potential as a therapeutic supplement has been hindered as it is rapidly metabolized and poorly absorbed. Liposomal delivery is the ultimate solution as it greatly increases the bioavailability of the compounds, enabling a much higher percentage to make it into the bloodstream intact. Our liposomes are made from natural phospholipid molecules that protect the resveratrol and curcumin, with a peak particle size of less than 50 nm (nanometers).

About Resveratrol & Curcumin

A variety of plants produce resveratrol as a protective response when dealing with a lack of nutrients, drought, UV radiation or to fend off bacteria, fungi and microbes. It’s prevalent in red and purple grapes, blueberries, raspberries, mulberries, peanuts and pistachios. Curcumin is the active compound in turmeric. Turmeric is a perennial plant, belonging to the ginger family and it is used as a spice in numerous culinary dishes. It is also consumed as a tea or as a supplement to help treat a variety of ailments.

About Antioxidants & Polyphenols

Antioxidants are molecules that work to fight free radicals, which are compounds that are harmful to the body when there are excessive amounts. Polyphenols play a vital role in longevity and cellular health and survival by protecting the body’s tissues against oxidative stress, inflammation, and age-related illnesses. (Source)

Liposomal Solves the Bioavailability Issue

Many popular supplements have very poor bioavailability. Here we demonstrate how Liposomes protect ingredients through the GI tract. Liposomes overcome obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. 1 Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes Demonstration

Why Liposomes Are Needed

Bioavailability Issues

Solves the Bioavailibility Problem

The aim of taking any supplement is to ensure its transport into the bloodstream via the mucosal and intestinal epithelial cells.However, due to low absorption and bioavailability rates of traditional oral dietary capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. 2 Liposomes are vesicles comprised of phospholipids—the primary building blocks of cell membranes. Because they are made of the same material our cell membranes are made of, as they bond to these membranes, they facilitate the delivery of nutrients that are difficult for your body to absorb.

Targeted Delivery

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. 3

Advanced Absorption

Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. A synthesis takes place which allows vitamins, minerals or micronutrients to be transported more easily. This higher absorption, means greater efficacy and with smaller doses needed to achieve better results. 4

Biocompatibility

Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. 5

Masking

Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6

Crosses the Blood Brain Barrier

Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. 7

Nanoscale Power

This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8

What are Liposomes made of?

The word liposome comes from the Greek words ‘lipo’ for fat and ‘soma’ for body. Liposomes are spherical ‘sacs’ consisting of a double ring of fatty-acid molecules—phosphatidylcholine molecules (phospholipid attached to a choline particle).The liposomal spherical ‘sac’ can be used to enclose and deliver contents of the ‘sac’ directly into the cells and body tissues.The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. This enables liposomes to be carriers of both hydrophobic and hydrophilic compounds. Liposomes are lipid vesicles made of phospholipids strung together, which form a double membrane, just like almost all cell membranes of our body.The encapsulation of hydrophilic or hydrophobic nutrients within liposomes, such as NMN, allows the active ingredient to bypass the destructive elements of the gastric system. improved its oral bioavailability and increase peak plasma concentration. 9

What does phosphatidylcholine do?

Phosphatidyl­choline is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10

How do Liposomes work?

Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.

References

1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave

Key Advantages of Liposomal Delivery:

  • Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
  • Optimizes both hydrophilic and hydrophobic, unstable compounds.
  • Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes.
  • Provides a larger nutrient payload per particle.
  • Offers higher bioavailability and absorption compared to conventional capsules.
  • Increases increase peak plasma concentration.

Research on Liposomes for Increased Bioavailability

Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2

Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3

Water Solubility

Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.

For best results, place two (2) pumps under the tongue twice per day and allow to absorb. May be taken with or without food.

For best results, place two (2) pumps under the tongue twice per day and allow to absorb. May be taken with or without food.

The pump mechanism is loaded. It may take 10-20 pumps to prime before first use. Target the tip of the pump under the tongue. Press down to administer LSG™. Put the cap back on the pump when finished. If swallowed, liposomes do protect the active ingredients from digestion in the stomach, but it is preferable to let the gel absorb under the tongue or elsewhere in the oral cavity as much as possible.

LSG™ NAD+ is nanoliposome-encapsulated Nicotinamide Adenine Dinucleotide, offering advanced absorption in sustained release sublingual hydrogel technology.

Our liposomes encapsulate NAD+ into nanometer sized vesicles – between 20-40 nm – to protect it from denaturation.

Our LSG delivery system protects the full functionality of NAD+.

NMN engulfed in liposomes protects it from degradation, providing its unmetabolized form directly to cells and tissues.

Store in a cool, dry, dark place.

EU countries only

For other countries, please use https://nadlab.uk/.

FREE delivery on orders over 200 euros

Once ordered and payment is received, we will dispatch your item(s) within four working days from a European distribution centre. You will receive an email with your tracking information.

There will be NO import duties, VAT, fees or taxes.

Standard tracked delivery by DHL or local mail is available to the following countries:

Delivery Charge€ 7.955-7 working days
AustriaBelgiumBulgaria
Czech RepublicDenmarkEstonia
FinlandFranceGermany
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NetherlandsRepublic of IrelandSpain - Mainland
Sweden
Delivery Charge€ 10.957-10 working days
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HungaryItalyLatvia
PolandPortugalRomania
SlovakiaSlovenia
Delivery Charge€ 17.9510-15 working days
Gibraltar
For the European countries below and the rest of the world, please order through NAD Lab UK - https://nadlab.uk

.
Canary Islands, Iceland, Liechtenstein, Norway, and Switzerland

Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below. We guarantee your satisfaction and will:

- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)

Return Procedures: Please email info@nadlab-eu.com with your complete name, address, phone # and order #. Once we receive this email, we will provide you with a return authorisation number and address. Please then return the package to us.

Once we receive your return package, you will receive your refund. You will either be credited back to your card or PayPal. Please allow 7 days to process the refund and 10 days to receive your refund by card.

NOTE: The customer is responsible for all delivery charges when sending the product back to us.

Call Monday-Friday between 9am and 5pm with any questions.

+44 (0) 3333 012 123