Resveratrol and Curcumin offer a powerhouse of antioxidant & anti-inflammatory benefits in this bioavailable liposomal gel. Resveratrol has shown great promise in clinical studies and is part of a group of compounds called polyphenols, which act as antioxidants to protect the body against age-related conditions. Curcumin is the active compound in turmeric and has an array of scientifically-proven health benefits.

Benefits May Include

• Support for cellular energy and mitochondrial function
• Activation of sirtuins, which are vital to regulating metabolic health, circadian rhythm, detoxification, and cellular aging
• Cardiovascular & Immune system support
• Support for joint health & inflammatory pain-related conditions

Bioavailability

Both resveratrol and curcumin are known to have poor bioavailability. In clinical studies, when resveratrol is taken orally, less than 1% of it makes it into the bloodstream, as it is rapidly and extensively metabolized in the intestines and liver. (Source)

Curcumin is known as a potent compound, but its full potential as a therapeutic supplement has been hindered as it is rapidly metabolized and poorly absorbed. Liposomal delivery is the ultimate solution as it greatly increases the bioavailability of the compounds, enabling a much higher percentage to make it into the bloodstream intact. Our liposomes are made from natural phospholipid molecules that protect the resveratrol and curcumin, with a peak particle size of less than 50 nm (nanometers).

About Resveratrol & Curcumin

A variety of plants produce resveratrol as a protective response when dealing with a lack of nutrients, drought, UV radiation or to fend off bacteria, fungi and microbes. It’s prevalent in red and purple grapes, blueberries, raspberries, mulberries, peanuts and pistachios. Curcumin is the active compound in turmeric. Turmeric is a perennial plant, belonging to the ginger family and it is used as a spice in numerous culinary dishes. It is also consumed as a tea or as a supplement to help treat a variety of ailments.

About Antioxidants & Polyphenols

Antioxidants are molecules that work to fight free radicals, which are compounds that are harmful to the body when there are excessive amounts. Polyphenols play a vital role in longevity and cellular health and survival by protecting the body’s tissues against oxidative stress, inflammation, and age-related illnesses. (Source)

Liposomal Solves the Bioavailability Issue

Many popular supplements have very poor bioavailability. Here we demonstrate how Liposomes protect ingredients through the GI tract. Liposomes overcome obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. ¹ Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Biocompatibility

Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. ⁵

Masking

Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. ⁶

Crosses the Blood Brain Barrier

Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. ⁷

Nanoscale Power

This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. ⁸

How do Liposomes work?

Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.

References

1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave

Research on Liposomes for Increased Bioavailability

Water Solubility

Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.