NAD+ AMPK Activator – Senolytic (60 Capsules)


  • 60 capsules per bottle
  • Liposomal Quercetin – 77 mg per capsule
  • Liposomal Fisetin – 35 mg per capsule
  • Liposomal Spermidine – 3 mg per capsule
  • cGMP Certified – This product is made in an FDA-approved facility
  • No artificial colours, flavours or preservatives. Non-GMO
  • Suitable for vegans

Activator is specially formulated to increase senolytic activity and stimulate AMPK production for increased NAD+ production inside cells and throughout the body.



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About Activator

Activator has been specially formulated with Lipo Quercetin, Lipo Fisetin, and Lipo Spermidine to be a powerful combination senolytic and AMPK activator.  As we age, we accumulate more and more senescent cells.

Senescent cells are cells that refuse to die, creating toxins that cause inflammation and play a causal role in ageing.  Supplements in Activator have been shown to eliminate a significant number of senescent cells, which in turn reduce the inflammation and ageing these cells cause.

Activator also includes AMPK activators that increase NAD+ and promote mitochondrial biogenesis, which creates new mitochondria that burn excess glucose and fats.  This allows them to be used for energy instead of storing them in the stomach and elsewhere in the body.

About Liposomal Delivery

Our Lipo products are part of a sustained-released liposomal delivery system that provides superior absorption in easy-to-swallow capsules.  Our process encapsulates and delivers our products intracellularly in their complete form where they can be absorbed and utilized rather than being destroyed in the stomach.

Lipo Quercetin

As a plant pigment, quercetin belongs to a group of plant compounds called flavonoids.  Flavonoids are compounds commonly found in: vegetables, fruits, grains, tea, and wine. Flavonoids are associated with a wide variety of health benefits.

Quercetin has been shown to selectively eliminate dangerous senescent cells, which secrete toxins that cause inflammation, without affecting healthy cells.  Senescent cells are also implicated in the ageing process, causing the degradation of NAD+ levels by the activation of CD38, a protein that is found on the cell membranes both inside and on the surface of many immune cells.


The flavonoids apigenin and quercetin inhibit CD38 activity in vitro


Research has shown that CD38 is inhibited by flavonoids, including quercetin and apigenin.  David Sinclair takes quercetin for its senolytic properties every day.

“Treatment of cells with apigenin or quercetin inhibits CD38 and promotes an increase in intracellular NAD+ levels” (1)

“researchers at the Buck Institute have identified chronic inflammation as a driver of NAD+ decline… via the activation of CD38” (2)

“It’s in a class of polyphenols from stressed plants (eg resveratrol) with broad health benefits in mice. I take 500 mg quercetin, a suspected senolytic and a SIRT1 activator.” – David Sinclair

Lipo Fisetin

Like quercetin, fisetin is yet another flavonoid that is a natural polyphenol and antioxidant.  Found in strawberries, apples, onions, and other plants that are particularly good at getting rid of senescent or “Zombie cells”, fisetin has been called “The King of Senolytics”.

In human trials at the prestigious Mayo Clinic, fisetin was shown to significantly reduce the number of senescent cells in adipose tissue, thereby reducing systemic inflammation and increasing strength and joint mobility in elderly test subjects.

The ability of fisetin to destroy senescent cells clears a path for NAD+ boosters to be much more effective by ridding the body of the toxins that create inflammation in the body, one of the main drivers of age-related diseases.


Fisetin reduced senescent cell burden in mice


Increased inflammation leads to more CD38 that consumes NAD+, which leads to more age-related diseases.  Removing senescent cells lowers inflammation and spares NAD+ from being consumed.

Fisetin has also been shown to increase NAD+ levels through the activation of AMPK, a key modulator of energy levels and the production of ATP, needed by mitochondria.

“We found that the AMPK/mTOR signaling pathway was enhanced after fisetin treatment” (3)

“Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity.” (6)

Lipo Spermidine

Spermidine is a naturally occurring molecule that is vital to cell function and survival. It’s part of a group of molecules called polyamines.  Declining polyamine levels are associated with inflammation-driven ageing.

“Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and polyamine (spermidine or high-polyamine diet) supplementation increases life span in model organisms.” (4)

Spermidine Induces Autophagy and Reduces Inflammation
Spermidine’s main mechanism of action is its ability to induce autophagy, a self-preservation process which clears out toxic, damaged and dysfunctional cells, resulting in lower levels of inflammation in the body.

Normally, the process of autophagy is induced by an extended period of fasting.  However, it can also be induced by compounds like Spermidine, which mimic the anti-ageing benefits of caloric restriction.

“A defective autophagy mechanism and a lack of spermidine are highly correlated with reduced life spans, chronic stress, and acute inflammation.” (5)

Spermidine Induces Autophagy and Reduces Inflammation

Spermidine’s main mechanism of action is its ability to induce autophagy, a self-preservation process which clears out toxic, damaged and dysfunctional cells, resulting in lower levels of inflammation in the body.

Normally, the process of autophagy is induced by an extended period of fasting.  However, it can also be induced by compounds like Spermidine, which mimic the anti-ageing benefits of caloric restriction.

“A defective autophagy mechanism and a lack of spermidine are highly correlated with reduced life spans, chronic stress, and acute inflammation.” (5)


Autophagy – the body’s self-cleaning cycle

Inflammation Is A Major Consumer of NAD+

Chronic inflammation is a risk factor for a wide range of age-related diseases and it’s a major consumer of NAD+.  In order to restore your NAD+ pool, minimizing inflammation is vital.

Spermidine’s Potential Impact On Aging

According to Dr. David Sinclair, professor of genetics at Harvard and one of the leading longevity scientists, Spermidine can reduce disease and lower bioage by 5.7 years.

“Spermidine, a tiny molecule from wheat germ, protects the heart and extends the lifespan of mice, even when given mid-life. In people, increased consumption is associated with fewer diseases & a 5.7-year age reduction.” – David A. Sinclair



1 – Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

2 – Chronic inflammation causes a reduction in NAD+

3 – Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways

4 – Polyamines in aging and disease

5 – Induction of autophagy by spermidine promotes longevity

6 – Fisetin is a senotherapeutic that extends health and lifespan

Liposomal Solves the Bioavailability Issue

Many popular supplements have very poor bioavailability. Here we demonstrate how Liposomes protect ingredients through the GI tract. Liposomes overcome obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. 1 Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes Demonstration

Why Liposomes Are Needed

Bioavailability Issues

Solves the Bioavailibility Problem

The aim of taking any supplement is to ensure its transport into the bloodstream via the mucosal and intestinal epithelial cells.However, due to low absorption and bioavailability rates of traditional oral dietary capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. 2 Liposomes are vesicles comprised of phospholipids—the primary building blocks of cell membranes. Because they are made of the same material our cell membranes are made of, as they bond to these membranes, they facilitate the delivery of nutrients that are difficult for your body to absorb.

Targeted Delivery

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. 3

Advanced Absorption

Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. A synthesis takes place which allows vitamins, minerals or micronutrients to be transported more easily. This higher absorption, means greater efficacy and with smaller doses needed to achieve better results. 4


Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. 5


Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6

Crosses the Blood Brain Barrier

Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. 7

Nanoscale Power

This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8

What are Liposomes made of?

The word liposome comes from the Greek words ‘lipo’ for fat and ‘soma’ for body. Liposomes are spherical ‘sacs’ consisting of a double ring of fatty-acid molecules—phosphatidylcholine molecules (phospholipid attached to a choline particle).The liposomal spherical ‘sac’ can be used to enclose and deliver contents of the ‘sac’ directly into the cells and body tissues.The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. This enables liposomes to be carriers of both hydrophobic and hydrophilic compounds. Liposomes are lipid vesicles made of phospholipids strung together, which form a double membrane, just like almost all cell membranes of our body.The encapsulation of hydrophilic or hydrophobic nutrients within liposomes, such as NMN, allows the active ingredient to bypass the destructive elements of the gastric system. improved its oral bioavailability and increase peak plasma concentration. 9

What does phosphatidylcholine do?

Phosphatidyl­choline is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10

How do Liposomes work?

Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.


1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave

Key Advantages of Liposomal Delivery:

  • Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
  • Optimizes both hydrophilic and hydrophobic, unstable compounds.
  • Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes.
  • Provides a larger nutrient payload per particle.
  • Offers higher bioavailability and absorption compared to conventional capsules.
  • Increases increase peak plasma concentration.

Research on Liposomes for Increased Bioavailability

Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2

Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3

Water Solubility

Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.

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Once ordered and payment is received, we will dispatch your item(s) within four working days from a European distribution centre. You will receive an email with your tracking information.

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For best results, take one (1) capsule daily as a dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.

Store in a cool, dry place.

Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below. We guarantee your satisfaction and will:

- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)

Return Procedures: Please email with your complete name, address, phone # and order #. Once we receive this email, we will provide you with a return authorisation number and address. Please then return the package to us.

Once we receive your return package, you will receive your refund. You will either be credited back to your card or PayPal. Please allow 7 days to process the refund and 10 days to receive your refund by card.

NOTE: The customer is responsible for all delivery charges when sending the product back to us.

Call Monday-Friday between 9am and 5pm with any questions.

+44 (0) 3333 012 123