Liposomal Vitamin D3 & K2 (60 servings)

 24,95

  • 60 servings per bottle
  • 2,500 IU Vitamin D3 and 200 mcg Vitamin K2 per serving
  • Sub-50 nanometer liposomes
  • Third party tested for purity and safety – see certificates attached
  • cGMP Certified – This product was made in an FDA approved facility
  • No artificial colours, flavours or preservatives. Non-GMO.
  • Gluten-free. Suitable for vegans

This Liposomal D3 & K2 is created through an all-natural manufacturing process where liposomes engulf and protect the D3 & K2 as it is digested, making more of the active compounds bioavailable.

The Liposomal manufacturing process uses no heat, no high pressure and a natural non-hydrogenated sunflower phosphatidylcholine derived from non-GMO certified sunflower. It undergoes a multi-step, purification and filtration process using Ultrapure Water.

 

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Description

Vitamin D: The “sunshine” vitamin

Vitamin D3 or cholecalciferol, is one of two forms of vitamin D. Both vitamin D2 and D3 need to be converted first by the liver and then by the kidneys into the main form of vitamin D, however D3 appears to be more effective at raising levels of active vitamin D than D2, which is why it is more highly recommended by healthcare providers.

Vitamin D is a fat-soluble vitamin found in various foods and supplements but which can also be made by the body when the skin is exposed to the ultraviolet rays from the sun. Vitamin D is the only vitamin out of all 13 essential vitamins that the body can manufacture on its own. Many people, however become deficient in vitamin D because they don’t get enough sunshine. This is why vitamin D is often known as the “sunshine vitamin” because the body’s main source of vitamin D is the sun.

Vitamin D deficiency is common

If you work inside or live in a cooler climate, however you may not be getting all the vitamin D you need. Simply wearing sunscreen can prevent your body from getting all the vitamin D it needs. To make matters worse, as you age your skin’s ability to manufacture vitamin D from the sun diminishes.

“Vitamin D insufficiency affects almost 50% of the population worldwide. An estimated 1 billion people worldwide, across all ethnicities and age groups, have a vitamin D deficiency. This pandemic of hypovitaminosis D can mainly be attributed to lifestyle and environmental factors that reduce exposure to sunlight, which is required for ultraviolet-B (UVB)-induced vitamin D production in the skin.” (1)

One of the many roles of vitamin D is to promote calcium absorption, allowing for proper bone mineralization and growth. It also has other diverse roles throughout the body, including the reduction of inflammation, metabolizing glucose, and supporting immune function.

Vitamin D also plays a vital role in supporting neuromuscular function. The body’s neuromuscular system includes the brain’s signaling system, from muscles to nerves. This communication system is important for the body’s coordinated movement. It is important that as we age, we maintain a healthy neuromuscular system through good nutrition and exercise.

Most experts recommend 600 to 800 IUs of vitamin D per day.

Vitamin K2 promotes bone and heart health

Controlled studies in humans have shown that vitamin K2 supplements generally improve bone and heart health. Among its most important functions are regulating calcium deposition, heart health, and blood clotting. K2 promotes the calcification of bones as well as preventing the calcification of blood vessels and kidneys.

A higher dose of vitamin K2 is strongly associated with a reduced risk of heart disease. Vitamin K2 also activates the calcium-binding actions of two proteins — osteocalcin and matrix GLA protein, both of which help to build and maintain bones. Vitamin K2 plays an essential role in bone metabolism and studies have shown that it can help prevent fractures and osteoporosis.

Vitamin K2 may be important for dental health

Based on some animal studies as well as the role vitamin K2 plays in bone metabolism, it’s suspected that K2 impacts dental health as well. One of the main regulating proteins in dental health is osteocalcin, which is the same protein critical for bone metabolism, activated by vitamin K2.

“Osteocalcin triggers a mechanism that stimulates the growth of new dentin, which is the calcified tissue underneath the enamel of your teeth.” (2)

Vitamin K2 may help fight cancer

There have been several studies on vitamin K2 and its affect on certain types of cancer. Two clinical studies in particular suggest that vitamin K2 reduces the recurrence of liver cancer and increases survival times.

In addition, an observational study in 11,000 men discovered that a high vitamin K2 intake was linked to a 63% lower risk of advanced prostate cancer. (3)

Liposomal D3 & K2 greatly enhances bioavailability

1 – Vitamin D: The “sunshine” vitamin

2 – Induction of type I collagen and osteocalcin in human dental pulp cells by retinoic acid

3 – Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition

LIPOSOMES SOLVE BIOAVAILABILITY ISSUE

Liposomes Demonstration

Why Liposomes are needed

Bioavailability Issues

Many popular supplements have very poor bioavailability. Here we demonstrate how Liposomes protect ingredients through the GI tract. Liposomes overcome obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.– more about the Liposome Advantage

Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. 1 Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites. – research on bioavailabilty with Liposomes

Solves the Bioavailibility Problem

The aim of taking any supplement is to ensure its transport into the bloodstream via the mucosal and intestinal epithelial cells.However, due to low absorption and bioavailability rates of traditional oral dietary capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. 2Liposomes are vesicles comprised of phospholipids—the primary building blocks of cell membranes. Because they are made of the same material our cell membranes are made of, as they bond to these membranes, they facilitate the delivery of nutrients that are difficult for your body to absorb.

Targeted Delivery

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. 3

Advanced Absorption

Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. A synthesis takes place which allows vitamins, minerals or micronutrients to be transported more easily. This higher absorption, means greater efficacy and with smaller doses needed to achieve better results. 4

Biocompatibility

Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. 5

Masking

Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6

Crosses the Blood Brain Barrier

Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. 7

Nanoscale Power

This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8

What are Liposomes made of?

The word liposome comes from the Greek words ‘lipo’ for fat and ‘soma’ for body. Liposomes are spherical ‘sacs’ consisting of a double ring of fatty-acid molecules—phosphatidylcholine molecules (phospholipid attached to a choline particle).The liposomal spherical ‘sac’ can be used to enclose and deliver contents of the ‘sac’ directly into the cells and body tissues.The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. This enables liposomes to be carriers of both hydrophobic and hydrophilic compounds. Liposomes are lipid vesicles made of phospholipids strung together, which form a double membrane, just like almost all cell membranes of our body.The encapsulation of hydrophilic or hydrophobic nutrients within liposomes, such as NMN, allows the active ingredient to bypass the destructive elements of the gastric system. improved its oral bioavailability and increase peak plasma concentration. 9

What does phosphatidylcholine do?

Phosphatidyl­choline is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10

How do Liposomes work?

Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.

References

1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave

Key Advantages of Liposomal Delivery:

  • Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
  • Optimizes both hydrophilic and hydrophobic, unstable compounds.
  • Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes.
  • Provides a larger nutrient payload per particle.
  • Offers higher bioavailability and absorption compared to conventional capsules.
  • Increases increase peak plasma concentration.

 

 

RESEARCH ON LIPOSOMES FOR INCREASED BIOAVAILABILITY

Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2

Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3

WATER SOLUBILITY

Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.

Take 2ml (just less than half a teaspoon) daily in water or juice, as a dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.

To maximise strength, refrigerate within 30 days after opening. Use within 90 days of opening.

EU countries only

For other countries, please use https://nadlab.uk/.

FREE delivery on orders over 200 euros

Once ordered and payment is received, we will dispatch your item(s) within four working days from a European distribution centre. You will receive an email with your tracking information.

There will be NO import duties, VAT, fees or taxes.

Standard tracked delivery by DHL or local mail is available to the following countries:

Delivery Charge€ 7.955-7 working days
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For the European countries below and the rest of the world, please order through NAD Lab UK - https://nadlab.uk

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Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below. We guarantee your satisfaction and will:

- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)

Return Procedures: Please email info@nadlab-eu.com with your complete name, address, phone # and order #. Once we receive this email, we will provide you with a return authorisation number and address. Please then return the package to us.

Once we receive your return package, you will receive your refund. You will either be credited back to your card or PayPal. Please allow 7 days to process the refund and 10 days to receive your refund by card.

NOTE: The customer is responsible for all delivery charges when sending the product back to us.

Call Monday-Friday between 9am and 5pm with any questions.

+44 (0) 3333 012 123