LIPO NMN (90 Capsules)
- 90 capsules per bottle
- Highly concentrated 250 mg liposomal Nicotinamide Mononucleotide (NMN) per capsule
- 100% Natural, Non-GMO
- Gluten-Free, Vegan Friendly
- Over 99% Purity (see lab analysis images)
LIPO NMN™ features our proprietary, powder-based liposomes made from natural phospholipid molecules that protect the NMN from digestive enzymes and carry them into the bloodstream for targeted systemic delivery.
FAST EU DELIVERY
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- What is a Liposome?
- Suggested Use
- Money Back Guarantee
ALIVE BY SCIENCE introduces LIPO Caps™ the Gold Standard in supplement delivery systems that provides maximum nutrient absorption throughout the body and is clinically proven to enhance the bioavailability up to 6x more than liquid liposome formulations(1)
Liposomes encapsulate active ingredients in a phospholipid “bubble” to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream.
They are specialized delivery vehicles serving multiple roles in enhancing the capabilities of active ingredients.
Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
– Protects ingredients from digestion in stomach and intestines
– Greatly increased circulation time in the bloodstream (not filtered out by liver)
BENEFITS OF LIPOSOMAL DELIVERY
Manufacturing liposomes does add cost to the finished product, which is why their usage has been more limited for vitamins and supplement as opposed to expensive pharmaceutical drugs. However, a 2x increase in cost is vastly outweight by the 5-20x or greater increase in effectiveness of liposomal delivery.
Many people realize liposomal delivery provides more “bang for the buck”, but it is clear they also enable much greater effectiveness and safety, and should be used for all products with known bioavailability problems.
MORE EFFECTIVE – HIGHER LEVELS OF SATURATION IN TARGET TISSUES
Many popular supplements such as Curcumin, Resveratrol, Berberine, Apigenin, Quercetin and others are well documented to have extremely poor bioavailability. When you’re taking a supplement that has 5% or less bioavailability, it is not possible to achieve high blood saturation levels safely. Liposomes deliver much higher quantities of the target molecules to the bloodstream.
SAFETY – MINIMIZES LIVER TOXICITY FROM EXCESSIVE DOSAGES
Many nutraceutical supplements have been shown to cause problems in the liver at higher dosages. The risk of liver damage greatly limits the dosage that can safely be used, which diminishes the effectiveness. The liver does not filter out molecules delivered by liposomes, so the risk from toxicity is greatly diminished.
POWDERED LIPOSOME NAD+ PRODUCTS
Our LIPO CAPS tm powdered liposomes technology encapsulates nanosized particles in liposomes, which are then freeze-dried to remove the aqueous phase. It’s a bit like grapes that are dehydrated to raisins, except that liposomes re-inflate in the body.
This ensures maximum bioavailability and stability, protecting the bio-active ingredients against degradation.
This encapsulation technology is clinically proven through safety, absorption and blood glucose studies to maximize nutrient bioavailability. (2)
A peak particle size of less than 50 nm (nanometers) ensures the maximum bioavailability and stability.
The advanced liposomes retain the core structure of the liposomal bilayer in its powder form, which stabilizes the active ingredient and ensures maximum bioefficiency, potency and absorption.
We use natural non-hydrogenated sunflower phosphatidylcholine in our manufacturing process, derived from non-GMO certified sunflower oil from Europe. It undergoes a multi-step, purification and filtration process during liposome manufacturing to ensure the utmost purity.
WHY LIPOSOMAL DELIVERY IS CRITICAL
If not protected, NAD+ metabolites are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver.
TOO MUCH NAM
This can be a problem when users believe more is better and take excessive doses of standard NR or NMN capsules. Very little makes it intact through the digestive tract, liver, and bloodstream to reach the target tissue. The result is massive increases in NAM.
For example, this study gave 300 mg/kg of NR to mice and found NAM is increased 40x, while NR is not increased and exists only at trace levels
“The minute amount of dual-labeled NAD observed in muscle indicates that direct utilization of NR by the muscle does occur. However, oral NR dosing increased circulating NAM ~40-fold while NMN remained unchanged and NR was detected only at trace levels in the blood. Thus, the majority of the orally administered NR that reaches the muscle appears to enter in the form of liberated NAM or as NMN.”
WHAT HAPPENS IF NAM LEVELS ARE TOO HIGH
High levels of NAM can have many negative effects such as inhibiting Sirtuins (r), which is the opposite of what you are trying to accomplish by taking NAD+ boosters. While NAM is beneficial for many health conditions, excessive NAM levels can be detrimental to your health.
“High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” (r)
The body does respond to try and bring NAM levels down, by attaching a Methyl group to the NAM to form MeNAM, which is then excreted. (r)
This can result in “methylation problems” where there are insufficient methyl donors that are critical for other needs and promotes age related health problems. (r)
TMG MAY HELP RESTORE METHYL GROUPS WHEN NAM LEVELS ARE TOO HIGH
As a result, it is common practice now for those taking NMN or NR to take TMG or other methyl donors. (r)
That is thought to help with the problem of excessive NAM buildup from taking high dosage NMN or NR capsules, but excess TMG can also lead to problems. (r)
LIPOSOMAL DELIVERY IS THE SOLUTION
A far better solution is to take a form of NMN or NR that protects the active ingredient from digestion to NAM.
Sublingual delivery of NMN delivers up to 30% of NMN to the bloodstream, so much less is digested to NAM and depletion of methyl groups is much less of a problem.
Liposomes are even better, as they can protect NAD+ metabolites from digestion and degradation in stomach, liver, and bloodstream.
Liposomal delivery prevents your expensive NAD+ precursors from being digested to NAM, which is a waste of money, and can actually be bad for your health.
Liposomes are vesicles comprised of phospholipid molecules – the same molecules that comprise cell membranes.
The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. These features enable liposomes to be the carriers of hydrophobic and hydrophilic compounds.
Due to low absorption and bioavailability rates of traditional oral dietary capsules, the encapsulation of hydrophilic and hydrophobic nutrients within liposomes allows the active ingredient to bypass the destructive elements of the gastric system.
To release the protected molecules to a site of action, the lipid bilayer fuses with other bilayers such as the cell membrane, delivering the liposome contents directly into the cells and tissues intact.
Our liposomes encapsulate NMN and NAD+ into nanometer sized vesicles – between 20-40 nm – to protect it from denaturation.
Our LSG delivery system protects the full functionality of NMN and NAD+.
NMN or NAD+ engulfed in liposomes protects it from degradation, providing its unmetabolized form directly to cells and tissues.
For best results, take one (1) capsule daily as a dietary supplement.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.
Store in a cool, dry place.
EU Orders only
FREE delivery on orders over 200 euros
Once ordered and payment has been received, your item(s) will be dispatched within two working days from a distribution center in Europe. You will receive an email with your tracking information.
There will be NO import duties, VAT, fees or taxes.
Standard tracked delivery by DHL or GLS is available to the following countries:
|Delivery Charge||€ 7.95||5-7 working days|
|Netherlands||Republic of Ireland||Spain - Mainland|
|Delivery Charge||€ 10.95||7-10 working days|
|Delivery Charge||€ 17.95||10-15 working days|
Guarantee and Return Policy
We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below.We guarantee your satisfaction and will:
- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)
Return Procedures: Please send an email to firstname.lastname@example.org with your complete name, address, phone # and your order # . Once we have received this email, we will provide you with a return authorisation number and return address. Please then return package to us.
Once we receive your return package, you will receive your refund. You will either be credited back to your Card, or PayPal. Please allow 7 days to process the refund and up to 10 working days to receive your refund by card.
NOTE: Customer is responsible for all delivery charges incurred when sending the product back to us.
Call Monday-Friday between 9am and 5pm with any questions.
+44 (0) 3333 012 123