LIPO Hyaluronic Acid HLA (90 Capsules)

 59,95

  • 90 capsules per bottle
  • Highly concentrated 150mg liposomal Hyaluronic Acid per capsule
  • Third party tested for purity and safety – see certificates attached
  • cGMP Certified – This product was made in an FDA approved facility
  • No artificial colours, flavours or preservatives. Non-GMO
  • Suitable for vegans

LIPO HLA™ features our proprietary, powder-based liposomes made from natural phospholipid molecules that protect High Molecular Weight Hyaluronic Acid from digestive enzymes and carry them into the bloodstream for targeted systemic delivery.

Our process encapsulates and delivers Hyaluronic Acid intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach.

 

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Description

LIPO HLA™ is a sustained-released liposomal delivery system that provides superior absorption of High Molecular Weight Hyaluronic Acid in easy-to-swallow capsules.

Our process encapsulates and delivers Hyaluronic Acid intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach.

A key molecule involved in skin hydration, joint health and bone integrity, the natural production of Hyaluronic Acid rapidly declines by up to 50% by the time we’re 50 years old. Studies show that consuming extra hyaluronic acid boosts the body’s natural production.

LIPO HLA™ offers advanced support for:

       ▸  Restoring youthful skin

       ▸  Reducing joint pain and inflammation

       ▸  Healthy digestion

       ▸  Preserving bone mass

 


What is Hyaluronic Acid?

Hyaluronic acid (a.k.a. hyaluronan, HA, or HLA) is a substance naturally found in many areas of the human body including the skin, eyes, and synovial fluid of the joints.


Preserves Tissue Hydration

More than 50% of the total body content of HLA is present in the skin.  (Source)

It plays a key role in maintaining extracellular spaces, preserving tissue hydration, and facilitating the transport of ion solutes and nutrients to cells in the upper layer of the skin because of its water-retaining capacity. (Source)


Holds 6000x its Volume

HLA is a humectant — a substance that retains moisture — and it is capable of binding over six thousand times its weight in water. (Source)

“HLA can bind up to 6000 times its volume in water, thus controlling tissue hydration.”


Dramatically Declines with Age

When we get older, hyaluronic acid levels in the skin decline. (Source)

A 70-year-old person has 75 percent less hyaluronic acid than a 19-year-old.

 

The natural aging process and exposure to things like ultraviolet radiation from the sun, tobacco smoke, and pollution can decrease its amounts in the skin. (Source)

“With aging, the epidermal HLA content decreases from 0.03% in women aged 19 to 47 years down to 0.015% in women aged 60 years and halves to 0.007% in women aged 70 years.” (Source)

 


In Older Skin, HLA Disappears from the Epidermis

“In senile skin, HLA is still present in the dermis, while HLA of the epidermis has disappeared entirely.  In addition, HLA polymers in senescent skin have a diminished ability to take on water of hydration with the consequence of a loss in skin moisture, commonly seen in aging skin.” (Source)

 

 

 

 

 

 

 

 


The most dramatic histochemical change observed in senescent skin is the marked decrease in epidermal HLA. With aging the epidermal HLA content decreases from 0,03% in women aged 19 to 47 years down to 0.007% in 70-year-old women.  (Source)

 


Oral HLA Relieves Wrinkles in a Double-Blind, Placebo-Controlled 12-Week Study

 

“After 8 weeks of ingestion, the HLA group showed significantly diminished wrinkles compared with the placebo group.  Skin luster and suppleness significantly improved after 12 weeks in all groups compared with the baseline.  The results suggest that oral HLA inhibits skin wrinkles and improves skin condition.” (Source)

 


Oral Doses of High Molecular Weight HLA Migrate to the Skin

 

Considering the role of HLA in the skin, it is suggested that the migration of HLA to the skin acts on the wrinkled skin as follows:

There are fibroblasts in the dermis of the skin. In these fibroblasts, collagen fibers, elastin fibers, and HLA are synthesized.  In vitro, HLA prompts the proliferation of fibroblasts of the dermis, and it was confirmed that intake of HLA promoted HLA synthesis in fibroblasts.

 

“Is is presumed that part of the orally ingested HLA promotes HLA synthesis in fibroblasts of the dermis, maintains normal skin, are is involved in the suppression of wrinkles.  In addition, because the fibroblast cells are growing, it is possible to suppress wrinkles by promoting collagen synthesis.  (Source)

 


Oral HLA Visibly Improves Wrinkles

 

 

Researchers have found HLA leads to efficacy against wrinkles, the improvement of subjective symptoms in the skin, and the improvement of skin conditions in multiple studies.

A recent study finds functionality through oral ingestion of HLA will require long-term continuous intake because the turnover for the skin is said to be 28 days.  (Source)

“It was confirmed that HLA is safe in humans when 200 mg/day HLA was ingested for 12 months; a long-term ingestion.”

Overall, intake of HLA over a longer period of time seems to have a positive impact on skin health.


Reduces Pain Due to Osteoarthritis

 

A number of trials have demonstrated that oral HLA intake improves symptoms of osteoarthritis.  (Source)

A randomized, double-blinded, placebo-controlled trial carried out between 2008 and 2015 has proven the effectiveness of HLA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength.


Oral Delivery of HLA Improved Knee Pain in Older Adults

Oral administration of HLA may improve the symptoms of knee osteoarthritis in patients aged 70 years or younger when combined with the quadriceps strengthening exercise. (Source)

According to this review, oral HA supplementation is effective in relieving osteoarthritis pain, synovial effusion, or inflammation, and improving muscular knee strength.


Greater Absorption with Liposomal Hyaluronic Acid

 

As HA is a big molecule, there have been some speculations about whether it can be absorbed.

Traditional HLA Supplements Degrade Quickly

Orally administered HLA typically show low absorption, or bioavailability, due to their degradation by enzymes in the gastrointestinal (GI) tract, the difficulty of absorbing them in the small intestine, and the first-pass metabolism in the liver.

“The most important limitations of HA are due to its short half-life and quick degradation in vivo and its consequently poor bioavailability.” (Source)

 

Liposomal HLA Directly Absorbed

Liposomes likeness to our living bilayer lipid cell membranes has a clear advantage for absorbing dietary supplements.

Creating this molecular mimicry allows our body to use its own mechanisms to directly absorb HLA into the tissue. (Source)

Liposomes likeness to our living bilayer lipid cell membranes has a clear advantage for absorbing dietary supplements. Creating this molecular mimicry allows our body to use its own mechanisms to directly absorb HLA into the tissue. (Source)


How do HLA Liposomes Work?

When the liposome merges with the lipid bilayer of the cell membrane, it can deliver its contents directly to the cell.

Liposomes are designed not only to protect the nutritional supplement from degrading and absorbing in the harsh environment of the gut terrain, but also to deliver the nutrients in a targeted manner to specific tissues and areas of the body.


Anti-inflammatory and Radical Scavenging Properties of HLA

HLA counteracts aging processes by its anti-inflammatory and radical scavenging properties. It can both be protective as a free radical scavenger and at the same time be a target for free radial stress. because it is itself harmed by the more toxic free radicals. (Source)


Possible HLA Longevity Benefits

Hyaluronic acid contains acetyl-glucosamine, a substance that extends lifespan in organisms. (Source)

Acetyl-glucosamine can reduce protein accumulation—a key driver of the aging process.

Scientists believe that acetyl-glucosamine may help extend lifespan by reducing protein accumulation and inducing a cellular repair response. (Source)

 

 

 

 

 

 

References

Liposomal Solves the Bioavailability Issue

Many popular supplements have very poor bioavailability. Here we demonstrate how Liposomes protect ingredients through the GI tract. Liposomes overcome obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. 1 Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.

Liposomes Demonstration

Why Liposomes Are Needed

Bioavailability Issues

Solves the Bioavailibility Problem

The aim of taking any supplement is to ensure its transport into the bloodstream via the mucosal and intestinal epithelial cells.However, due to low absorption and bioavailability rates of traditional oral dietary capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. 2 Liposomes are vesicles comprised of phospholipids—the primary building blocks of cell membranes. Because they are made of the same material our cell membranes are made of, as they bond to these membranes, they facilitate the delivery of nutrients that are difficult for your body to absorb.

Targeted Delivery

Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. 3

Advanced Absorption

Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. A synthesis takes place which allows vitamins, minerals or micronutrients to be transported more easily. This higher absorption, means greater efficacy and with smaller doses needed to achieve better results. 4

Biocompatibility

Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. 5

Masking

Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6

Crosses the Blood Brain Barrier

Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. 7

Nanoscale Power

This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8

What are Liposomes made of?

The word liposome comes from the Greek words ‘lipo’ for fat and ‘soma’ for body. Liposomes are spherical ‘sacs’ consisting of a double ring of fatty-acid molecules—phosphatidylcholine molecules (phospholipid attached to a choline particle).The liposomal spherical ‘sac’ can be used to enclose and deliver contents of the ‘sac’ directly into the cells and body tissues.The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. This enables liposomes to be carriers of both hydrophobic and hydrophilic compounds. Liposomes are lipid vesicles made of phospholipids strung together, which form a double membrane, just like almost all cell membranes of our body.The encapsulation of hydrophilic or hydrophobic nutrients within liposomes, such as NMN, allows the active ingredient to bypass the destructive elements of the gastric system. improved its oral bioavailability and increase peak plasma concentration. 9

What does phosphatidylcholine do?

Phosphatidyl­choline is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10

How do Liposomes work?

Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.

References

1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave

Key Advantages of Liposomal Delivery:

  • Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
  • Optimizes both hydrophilic and hydrophobic, unstable compounds.
  • Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes.
  • Provides a larger nutrient payload per particle.
  • Offers higher bioavailability and absorption compared to conventional capsules.
  • Increases increase peak plasma concentration.

Research on Liposomes for Increased Bioavailability

Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2

Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3

Water Solubility

Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.

For best results, take one (1) capsule daily as a dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.

Store in a cool, dry place.

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For other countries, please use https://nadlab.uk/.

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Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below. We guarantee your satisfaction and will:

- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)

Return Procedures: Please email info@nadlab-eu.com with your complete name, address, phone # and order #. Once we receive this email, we will provide you with a return authorisation number and address. Please then return the package to us.

Once we receive your return package, you will receive your refund. You will either be credited back to your card or PayPal. Please allow 7 days to process the refund and 10 days to receive your refund by card.

NOTE: The customer is responsible for all delivery charges when sending the product back to us.

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