LIPO Apigenin (90 Capsules)
€ 59,95
- 90 capsules per bottle
- Highly concentrated 35mg liposomal Apigenin per capsule
- Third party tested for purity and safety – see certificates attached
- cGMP Certified – This product was made in an FDA approved facility
- No artificial colours, flavours or preservatives. Non-GMO
- Suitable for vegans
LIPO Apigenin™ is a sustained-released liposomal delivery system that provides superior absorption of Apigenin in easy-to-swallow capsules.
Our process encapsulates and delivers Apigenin intracellularly in its complete form where it can be absorbed and utilized rather than being destroyed in the stomach.
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- Description
- What is a Liposome?
- Suggested Use
- Delivery
- Money Back Guarantee
Description
LIPO Apigenin™ is a sustained-released liposomal delivery system that provides superior absorption of Apigenin in easy-to-swallow capsules.
Our process encapsulates and delivers Apigenin intracellularly in its complete form where it can be absorbed and utilised rather than being destroyed in the stomach.
Apigenin is a naturally-occurring bioactive plant polyphenol with antioxidant, anti-inflammatory, antiviral and neuroprotective properties. Increasing Apigenin in the body has been shown to enhance cognition, stimulate the immune system, diminish oxidative stress and improve cellular detoxification.
LIPO Apigenin™ offers advanced support for:
▸ Neuroprotection
▸ Inflammation
▸ Blood glucose metabolism
▸ Nervous system function
Apigenin – a powerful new anti-aging and performance enhancing supplement
Apigenin is a naturally-occurring bioactive plant polyphenol with antioxidant, anti-inflammatory, antiviral, and neuroprotective properties. However, recent research has shown that Apigenin also has a powerful, new anti-aging and performance enhancing benefit as well.
How senescent cells affect NAD+ levels
As we age, we accumulate senescent or “zombie” cells, cells that have reached their limit of cell division and would normally be swept away and replaced by younger cells. Instead, these cells hang around and begin to secrete toxins called SASP factors which increase systemic inflammation, one of the hallmarks of ageing. The rising levels of inflammation cause an increase in an enzyme called CD38, a big consumer of NAD+, causing systemic NAD+ levels to drop.
“Our data suggest a link between cellular senescence and NAD+ decline in which SASP-mediated up-regulation of CD38 can disrupt cellular NAD+ homeostasis.” (1)
Fighting declining levels of NAD+ with Apigenin
Apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels.
“In a recent manuscript, we challenged this paradigm and demonstrated that levels and activity of the NADase CD38 increase during ageing, and that this enzyme is the main NAD-consuming enzyme responsible for the ageing-related NAD+ decline. We showed that the activity of CD38, but not PARP, increases in several tissues during the ageing process, and that genetic ablation of CD38 protects against age-related NAD+ decline and, mitochondrial dysfunction.” (2)
Apigenin could raise NAD+ levels, improve mitochondrial function and endurance performance
In a recent 6-week controlled human trial on the effects of NMN on runners, it was found that moderate to high levels of NMN boosted performance.
“Analysis of covariance of the change from baseline over the 6 week treatment showed that the oxygen uptake (VO2), percentages of maximum oxygen uptake (VO2max), power at first ventilatory threshold, and power at second ventilatory threshold increased to a higher degree in the medium and high dosage groups compared with the control group.” (3)
Significantly, other studies have found that lowering CD38 levels (using a CD38 inhibitor called 78c) not only increased NAD+ levels but also improved mitochondrial function and endurance performance.
“Deletion of PARP-1 or CD38, or the inhibitor of CD38 or PARP-1, improves mitochondrial function and endurance performance in mice.” (4)
“Thus, we tested the effect of 78c on metabolic parameters in mice at different ages. As expected, aged mice (2 years old) had lower tissue NAD+ levels, and worse glucose tolerance compared with younger mice. 78c promoted a significant increase in NAD+ levels in tissues of aged mice but had a negligible effect on NAD+ levels of young mice (3 months old).” (4)
Apigenin may decrease CD38 and senescent (zombie) cells
This study found Apigenin decreases senescent cells, resulting in less CD38.
Apigenin reduced senescence-associated activity and promoted cell growthApigenin also increased the activation ratio of silent information regulator 1 (SIRT1), and inhibited CD38 activity in a concentration-dependent manner.Our findings suggest that apigenin is a promising phytochemical for reducing the impact of senescent cells (5)
Enhanced Efficacy of Apigenin Liposomes
As with other bioflavonoids, the bioavailability of Apigenin is extremely low (Source).
Poor aqueous solubility, chemical instability, and low oral bioavailability significantly limits its applications. (Source)
“oral bioavailability of APG is relatively low because of its low aqueous solubility (2.16 μg/mL in water), [2] which has severely limited its further clinical development. Therefore, it is necessary to develop a novel formulation using advance strategies to improve APG oral bioavailability”
Under the Biopharmaceutics Classification System, Apigeninis classified as a class IV compound (low solubility, low permeability). (Source)
A recent study focusing on establishing apigenin as a potential chemotherapeutic agent for alleviating colorectal cancer reports the development of a stable liposomal nanocarrier with high encapsulation of the hydrophobic flavone apigenin for enhanced chemotherapeutic effects.
“Apigenin liposomes bypass the hurdles posed by apigenin as a chemotherapeutic due to its high hydrophobicity. The enhanced pharmacological activity of apigenin has been assigned to its ability to interact and subsequently influence membrane properties which also resulted in optimal yield of a stable, rigidified, non-leaky nano-carrier with ideal release kinetics.” (6)
References
Liposomal Solves the Bioavailability Issue
Many popular supplements have very poor bioavailability. Here we demonstrate how Liposomes protect ingredients through the GI tract. Liposomes overcome obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
Liposomes are a revolutionary way of encapsulating active ingredients to protect and deliver them directly to the cells of our tissues, which are reached via the bloodstream. 1 Liposomes stabilize therapeutic compounds—overcoming obstacles to cellular and tissue uptake—and improve the biodistribution of compounds to target sites.
Liposomes Demonstration
Why Liposomes Are Needed
Bioavailability Issues
Solves the Bioavailibility Problem
The aim of taking any supplement is to ensure its transport into the bloodstream via the mucosal and intestinal epithelial cells.However, due to low absorption and bioavailability rates of traditional oral dietary capsules, active ingredients lose most of their potency while passing through the gastrointestinal tract or are simply not absorbed in the small intestine at all. The majority is excreted unused via the intestines or kidneys. 2 Liposomes are vesicles comprised of phospholipids—the primary building blocks of cell membranes. Because they are made of the same material our cell membranes are made of, as they bond to these membranes, they facilitate the delivery of nutrients that are difficult for your body to absorb.
Targeted Delivery
Liposomal delivery offers a targeted and complete absorption of active ingredients with a delayed‑release effect, unlike all other nutrient delivery methods. This increased circulation time of key nutrients in the bloodstream significantly bioavailability. The higher the bioavailability of an active substance, the more effect it has on the body. 3
Advanced Absorption
Liposomes are absorbed through the oral mucosal lining and through lymphatic mechanisms in the gut, bypassing first pass metabolism and breakdown in the liver ensuring the retention of liposome integrity. A synthesis takes place which allows vitamins, minerals or micronutrients to be transported more easily. This higher absorption, means greater efficacy and with smaller doses needed to achieve better results. 4
Biocompatibility
Phospholipids, which are found throughout the body in the membranes of body cells, are so naturally-occurring, that the body recognizes these as body-compatible and does not treat them as ‘toxic’ or ‘foreign’—and, so, does not mount an immune attack on the liposome. 5
Masking
Liposomes shield nutrients from detection by the body’s immune system, mimicking biological membranes and giving the active ingredients more time to reach their intended destination. Phospholipids mask the active ingredients so that larger amounts can be absorbed and escape the selective function of the small intestine. Osmotic (hydrophilic) side effects of some high-dose vitamins and minerals can thus be reduced. 6
Crosses the Blood Brain Barrier
Liposomes have demonstrated the ability to cross this barrier, giving the liposomes the ability to deposit the supplement directly into the cells and enhance circulation of nutrients by your lymphatic system. 7
Nanoscale Power
This profound effect of liposome size on complement recognition can also affect liver uptake. Generally, large unmodified liposomes are eliminated more rapidly than small liposomes, which is why our Fluidizing Liposomes™ are very small—less than 100 nm to prevent their uptake by macrophages of the liver and the spleen. 8
What are Liposomes made of?
The word liposome comes from the Greek words ‘lipo’ for fat and ‘soma’ for body. Liposomes are spherical ‘sacs’ consisting of a double ring of fatty-acid molecules—phosphatidylcholine molecules (phospholipid attached to a choline particle).The liposomal spherical ‘sac’ can be used to enclose and deliver contents of the ‘sac’ directly into the cells and body tissues.The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. This enables liposomes to be carriers of both hydrophobic and hydrophilic compounds. Liposomes are lipid vesicles made of phospholipids strung together, which form a double membrane, just like almost all cell membranes of our body.The encapsulation of hydrophilic or hydrophobic nutrients within liposomes, such as NMN, allows the active ingredient to bypass the destructive elements of the gastric system. improved its oral bioavailability and increase peak plasma concentration. 9
What does phosphatidylcholine do?
Phosphatidylcholine is required for many vital functions in the cardiovascular, reproductive, immune, and nervous systems. PC and its components are needed for the synthesis of important messenger molecules called prostaglandins which, among other functions, regulate the contraction and relaxation of muscles. Choline is required for the synthesis of intracellular messenger molecules including the neurotransmitters that allow nerve cells to communicate with muscles and each other, and are essential for proper heart and brain function. At birth up to 90% of cellular membranes are made up of PC. As you age, the percentage of PC in your cellular membranes can decrease to about 10%. This fact leads many to recommend consistent supplementation with this essential phospholipid. 10
How do Liposomes work?
Liposomes release bioactive nutrients by membrane fusion. They delay the clearance and increase the intravascular circulation time of encapsulated nutrients and prolonging retention time. At the first stage of liposome-cell interaction, liposomes adhere to the cell surface. Following such binding, the liposome is internalized into the cell by the mechanism of endocytosis (or phagocytosis). This is followed by the enzymatic digestion of the liposome in the intracellular compartment, accompanied by the intracellular distribution. The active nutrient encapsulated in the liposome is protected from metabolism and the molecule becomes active only after release from liposome. These encapsulating phospholipids bond with cell membranes to facilitate intracellular delivery. They are successful in this because they are able to bypass the digestive processes that normally degrade foreign substances. Liposomes ensure safe delivery of encapsulated cargo retain it in tissues and cells.
References
1. Potential of Liposomes for Enhancement of Oral Drug Absorption 2. Nanocarriers for oral drug delivery 3. Composition design and medical application of liposomes 4. Liposomal Delivery Systems: Design Optimization and Current Applications 5. Oral Bioavailability: Issues and Solutions via Nanoformulations 6. Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery 7. Stabilization of liposomes during drying 8. Powdered lipid nano and microparticles: production and applications. Lipid nanoparticles as vehicles for macromolecules: nucleic acids and peptides 9. Scalable solvent-free production of liposomes 10. Membrane lipids: where they are and how they behave
Key Advantages of Liposomal Delivery:
- Protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
- Optimizes both hydrophilic and hydrophobic, unstable compounds.
- Timing of the dose does not require accompaniment or exclusion of food as the absorption via the liposome avoids the digestive processes.
- Provides a larger nutrient payload per particle.
- Offers higher bioavailability and absorption compared to conventional capsules.
- Increases increase peak plasma concentration.
Research on Liposomes for Increased Bioavailability
Liposomes, vesicles enclosed by phospholipid bilayers, can solubilize water-insoluble drugs into the lipid domain of the liposomal membrane. In addition to their solubilizing capacity and biocompatibility, the structural and compositional similarity of liposomes with bio-membranes has also encouraged their application for non-invasive oral delivery of poorly-permeable nutrients. 2
Liposomes are non-toxic, biocompatible, biodegradable, and have the following advantages as carriers in drug delivery: first, liposomes can reduce toxicity; second, hydrophilic and lipophilic agents can be incorporated into liposomes; third, liposomes control the drug release; and fourth, the liposome delivery system increases bioavailability. 3
Water Solubility
Molecules with very poor water solubility usually have the worst bioavailability and can benefit the most from liposomal delivery. Fisetin is one example shown below up to 27x more bioavailable.
For best results, take one (1) capsule daily as a dietary supplement.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a doctor before using.
Store in a cool, dry place.
EU countries only
For other countries, please use https://nadlab.uk/.
FREE delivery on orders over 200 euros
Once ordered and payment is received, we will dispatch your item(s) within four working days from a European distribution centre. You will receive an email with your tracking information.
There will be NO import duties, VAT, fees or taxes.
Standard tracked delivery by DHL or local mail is available to the following countries:
| Delivery Charge | € 7.95 | 5-7 working days |
|---|---|---|
| Austria | Belgium | Bulgaria |
| Czech Republic | Denmark | Estonia |
| Finland | France | Germany |
| Luxemburg | Malta | Monaco |
| Netherlands | Republic of Ireland | Spain - Mainland |
| Sweden |
| Delivery Charge | € 10.95 | 7-10 working days | |
|---|---|---|---|
| Croatia | Cyprus | Greece | |
| Hungary | Italy | Latvia | |
| Poland | Portugal | Romania | |
| Slovakia | Slovenia |
| Delivery Charge | € 17.95 | 10-15 working days |
|---|---|---|
| Gibraltar |
For the European countries below and the rest of the world, please order through NAD Lab UK - https://nadlab.uk
.
Canary Islands, Iceland, Liechtenstein, Norway, and Switzerland
Guarantee and Return Policy
We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below. We guarantee your satisfaction and will:
- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)
Return Procedures: Please email info@nadlab-eu.com with your complete name, address, phone # and order #. Once we receive this email, we will provide you with a return authorisation number and address. Please then return the package to us.
Once we receive your return package, you will receive your refund. You will either be credited back to your card or PayPal. Please allow 7 days to process the refund and 10 days to receive your refund by card.
NOTE: The customer is responsible for all delivery charges when sending the product back to us.
Call Monday-Friday between 9am and 5pm with any questions.
+44 (0) 3333 012 123
