Fisetin Liposomal Sublingual Gel (60 Servings)

 89,95

  • 75 mg Fisetin (98% pure) per serving
  • 1 serving = 2 pumps
  • 60 servings per bottle
  • 100% Natural, Non-GMO
  • Gluten-Free, Vegan Friendly

Liposomal Sublingual Gel™ (LSG) Fisetin is designed for sublingual (under the tongue) use for superior bioavailability. Our proprietary liposomal manufacturing process uses no heat, no pressure and only high-performance, pharmaceutical-grade ingredients.

 

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Description

Liposomal Fisetin up to 47x more bioavailable

Fisetin administration is complicated by its low water solubility. Taken orally, fisetin is converted to an inactive form in the body.  But scientists have discovered that protecting fisetin in a liposome enhances permeation into cells.  (Source)

“Because of fisetin’s limited water solubility, we designed a liposomal formulation and evaluated its biological properties in vitro and in Lewis lung carcinoma (LLC) bearing mice.” (Source)

The challenge up until now was that fisetin is converted to an inactive form in the digestive tract. This means very little is absorbed into the bloodstream.

Fisetin-loaded liposomes have been shown to improve the solubility of fisetin and increase its blood residence time.

New studies show liposomal fisetin is up to 47x more bioavailable, which allows smaller dosages that put less strain on the liver.  (Source)

“In vivo, liposomal fisetin allowed a 47-fold increase in relative bioavailability compared to free fisetin.

The effect of liposomal fisetin on LLC tumor growth in mice at low dose (21 mg/kg) allowed a higher tumor growth delay.

In conclusion, fisetin liposomes markedly improved fisetin bioavailability and anticancer efficacy in mice and this formulation could facilitate the administration of this flavonoid in the clinical setting.”  (Source)

Why Fisetin?

Thanks to a new study published in Nature Medicine, we now have a convincing culprit for age-related physical dysfunction: the accumulation of “zombie” senescent cells. We might be able to fight off senescent cells and their inflammatory secretions with interventions including senolytic drugs, exercise and intermittent fasting.

“Senescence can be induced by such stresses as DNA damage, telomere shortening, oncogenic mutations, metabolic and mitochondrial dysfunction, and inflammation. Senescent cell burden increases in multiple tissues with aging, at sites of pathology in multiple chronic diseases, and after radiation or chemotherapy.” — Xu et al., 2018

Senescent cells are defective older cells that are no longer functioning as they should. Most are cleared out and recycled by our immune systems, but as we age, more and more of these defective cells build up.

Sometimes called “zombie cells”, they cause significant harm by secreting molecules that cause inflammation to surrounding cells, leading to more impairment.

Increased systemic inflammation is now recognised as a leading contributor to all age related disease and ageing itself. Clearing out of senescent cells can lower systemic inflammation and turn back ageing to some degree.

https://www.ebiomedicine.com/article/S2352-3964(18)30373-6/fulltext

This new study found that Fisetin is more effective than any currently know senolytic compound, destroying 25-50% of senescent cells. The dose used equates to 500 mg per day for five days for a 60kg human.

This current research with Fisetin was exciting because it is:

  • very effective at clearing senescent cells
  • a well studied natural product with very good safety profile
  • has many well documented health benefits
  • not required to use daily
  • has already passed phase 1 safety tests in humans

Liposomes are vesicles comprised of phospholipid molecules – the same molecules that comprise cell membranes.

The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. These features enable liposomes to be the carriers of hydrophobic and hydrophilic compounds.

Due to low absorption and bioavailability rates of traditional oral dietary capsules, the encapsulation of hydrophilic and hydrophobic nutrients within liposomes allows the active ingredient to bypass the destructive elements of the gastric system.

To release the protected molecules to a site of action, the lipid bilayer fuses with other bilayers such as the cell membrane, delivering the liposome contents directly into the cells and tissues intact.

Alive By Nature LSG™ (Liposomal Sublingual Gel) – An Innovation in Liposome Science

The pump mechanism is loaded. It may take 7-10 pumps to prime before release. Target the tip of the pump under the tongue. Press down to administer LSG™. Put the cap back on the pump when done.
LSG™ is nanoliposome-encapsulated offering advanced absorption in sustained release sublingual hydrogel technology.

Our liposomes encapsulate Resveratrol & Curcumin into nanometer sized vesicles – between 20-40 nm – to protect it from denaturation.

Our LSG delivery system protects the full functionality of Resveratrol & Curcumin.

Resveratrol & Curcumin engulfed in liposomes protects it from degradation, providing its unmetabolized form directly to cells and tissues.

Find out more from Alive By Nature

For best results, place two (2) pumps under the tongue twice per day and allow to absorb. May be taken with or without food.

The pump mechanism is loaded. It may take 7-10 pumps to prime before release. Target the tip of the pump under the tongue. Press down to administer LSG™. Put the cap back on the pump when done.

LSG™ NAD+ is nanoliposome-encapsulated Nicotinamide Adenine Dinucleotide, offering advanced absorption in sustained release sublingual hydrogel technology.

Our liposomes encapsulate NAD+ into nanometer sized vesicles – between 20-40 nm – to protect it from denaturation.

Our LSG delivery system protects the full functionality of NAD+.

NMN engulfed in liposomes protects it from degradation, providing its unmetabolized form directly to cells and tissues.

Store in a cool, dry, dark place.

EU Orders only

FREE delivery on orders over 200 euros

Once ordered and payment has been received, your item(s) will be dispatched within two working days from a distribution center in Europe. You will receive an email with your tracking information.

There will be NO import duties, VAT, fees or taxes.

Standard tracked delivery by DHL or GLS is available to the following countries:

Delivery Charge€ 7.955-7 working days
AustriaBelgiumBulgaria
Czech RepublicDenmarkEstonia
FinlandFranceGermany
LuxemburgMaltaMonaco
NetherlandsRepublic of IrelandSpain - Mainland
Sweden
Delivery Charge€ 10.957-10 working days
CroatiaCyprusGreece
HungaryItalyLatvia
PolandPortugalCanary Islands
SlovakiaSlovenia
Delivery Charge€ 17.9510-15 working days
Gibraltar
For the European countries below and the rest of the world, please order through NAD Lab UK - https://nadlab.uk

Iceland, Liechtenstein, Norway, and Switzerland

Guarantee and Return Policy

We offer a 30-day Money Back Satisfaction Guarantee from the date you received the product. Please read the terms and conditions below.We guarantee your satisfaction and will:

- Issue a full refund for unopened products
- Issue a refund of 50% of the purchase price for returned products that have at least 50% of the product remaining (this does not apply to the Pure NMN Sublingual Powder 100g product)

Return Procedures: Please send an email to info@nadlab-eu.com with your complete name, address, phone # and your order # . Once we have received this email, we will provide you with a return authorisation number and return address. Please then return package to us.

Once we receive your return package, you will receive your refund. You will either be credited back to your Card, or PayPal. Please allow 7 days to process the refund and up to 10 working days to receive your refund by card.

NOTE: Customer is responsible for all delivery charges incurred when sending the product back to us.

Call Monday-Friday between 9am and 5pm with any questions.

+44 (0) 3333 012 123